Below is an account from "Chronicles of Border Warfare" RE John McIntire.  According to Bob Sapp, this John is son of his Charles.                      

This event appears to take place at or near Big Bottom at settlements made up the Muskingam River in Ohio:
 

    [... 294]  In May (1791), John McINTIRE and his wife were returning from a visit, they passed through the yard of Uriah ASHCRAFT; and in a small space of time after, Mr. ASHCRAFT, startled by the sudden growling and springing up of one of his dogs, stepped quickly to the door to see what had aroused him.  He had hardly reached the door when he espied an Indian on the outside with his gun presented.  Closing and making fast the door, he ascended the stairs that he might better fire upon the unwelcome intruder; and after snapping three several times, and having discovered that there were other Indians in the yard, he raised a loud shout to apprize those who were within the sound of his voice, that he was surrounded by danger.  Upon this the Indians moved off ; and three brothers of McIntire coming to his relief, they all pursued the trail of the savages.  About a mile from Ashcraft's, they found the body of John McINTIRE, tomahawked, scalped, and stripped; and concluding that Mrs. McINTIRE, was taken prisoner, they sent intelligence to Clarksburg of what had happened, and requested assistance to follow the Indians and recover the prisoner from captivity. The desired assistance was immediately afforded; and a company of men, led on by Col. John HAYMOND and Col. George JACKSON, went in pursuit. On Middle Island Creek, before they were aware of their proximity to the savages, they were fired upon by them, [295] and two of the party very narrowly escaped being shot.   -- A ball passed through the hankerchief on the head of Col. HAYMOND and  another through the sleeve of Col. JACKSON's shirt. The fire was promptly returned, and the men rushed forward. The Indians however, made their retreat, though not without having experienced some injury; as was discovered by the blood, and the throwing down of some of the plunder which they had taken. It was here first ascertained that Mrs. McINTIRE had been killed, -- her scalp being among the things left -- and on the return of the party, her body was found some small distance from where that of her husband had been previously discovered.
 

Notes by James F. McIntire (1999) – from information provided by Robert A Sapp: 

Uriah Ashcraft (b. 4/5/1765; d. 4/21/1842) was married (10/7/1788, Harrison Cop., VA, John Denham performed the wedding) to Sarah McIntire (b. 12/17/1774; d. 1/26/1847), sister of John, daughter of Charles.

 John McIntire (b. c. 1754, Frederick Co. VA; d. May 1791, Harrison Co., VA) married Rachael Rose (d. May 1791, Harrison Co., VA)

McIntire brothers that chased the Indians were probably Samuel, Charles, Jr., and James