description | the role of the Chorus | the elements | thesmophoria | the music | the performers

the sound synthesis consists of three sound layers:

1. the background 'environmental' synthesis, based on the DNA sequences of the mutant fruitflies.

2. the male foreground synthesis based on the thermal scanning of space. Thermal outputs are transformed to skirl real-time sounds

3. the female chorus, consisting of seven women which periodically sing a synthesis based on abuses.


the mutant fruitflies

One of the most striking mutations in Drosophila is the conversion of antennae into legs by the gain-of-function dominant mutation, Antennapedia.

HOMEOTIC TRANSFORMATIONS involving the Antennapedia Complex (ANTC)
Adult fly heads: wild type, antennapedia (antennae transformed to 2nd thoracic legs) and a double mutant proboscipedia/ antennapedia (antennae to 2nd thoracic and proboscis to 1st thoracic legs).

How music is derived from the DNA sequence of the mutant fruitfly

Music Fly
The DNA of a fly (
894 bases) is used as a base for the production of music. A specific algorithm will be designed for the interpretation of the DNA code. This music piece is then arranged to aesthetic preference and transformed to a new DNA sequence which becomes a representation of a new fly. This new organism might be produced in the lab or as a computer model.

The 894 bases of the antenappedia gene:
1 atgacgatga gtacaaacaa ctgcgagagc atgacctcgt acttcaccaa ctcgtacatg
61 ggggcggaca tgcatcatgg gcactacccg ggcaacgggg tcaccgacct ggacgcccag
121 cagatgcacc actacagcca gaacgcgaat caccagggca acatgcccta cccgcgcttt
181 ccaccctacg accgcatgcc ctactacaac ggccagggga tggaccagca gcagcagcac
241 caggtctact cccgcccgga cagcccctcc agccaggtgg gcggggtcat gccccaggcg
301 cagaccaacg gtcagttggg tgttccccag cagcaacagc agcagcagca acagccctcg
361 cagaaccagc agcaacagca ggcgcagcag gccccacagc aactgcagca gcagctgccg
421 caggtgacgc aacaggtgac acatccgcag cagcaacaac agcagcccgt cgtctacgcc
481 agctgcaagt tgcaagcggc cgttggtgga ctgggtatgg ttcccgaggg cggatcgcct
541 ccgctggtgg atcaaatgtc cggtcaccac atgaacgccc agatgacgct gccccatcac
601 atgggacatc cgcaggcgca gttgggctat acggacgttg gagttcccga cgtgacagag
661 gtccatcaga accatcacaa catgggcatg taccagcagc agtcgggagt tccgccggtg
721 ggtgccccac ctcagggcat gatgcaccag ggccagggtc ctccacagat gcaccaggga
781 catcctggcc aacacacgcc tccttcccaa aacccgaact cgcagtcctc ggggatgccg
841 tctccactgt atccctggat gcgaagtcag tttggtaagt gtcaaggaaa gtga

antenappedia protein sequence

MTMSTNNCESMTSYFTNSYMGADMHHGHYPGNGVTDLDAQQMHHYSQNANHQGNMPYPRFPPYDRMP
YYNGQGMDQQQQHQVYSRPDSPSSQVGGVMPQAQTNGQLGVPQQQQQQQQQPSQNQQQQQAQQAPQQL
QQQLPQVTQQVTHPQQQQQQPVVYASCKLQAAVGGLGMVPEGGSPPLVDQMSGHHMNAQMTLPHHMGHP
QAQLGYTDVGVPDVTEVHQNHHNMGMYQQQSGVPPVGAPPQGMMHQGQGPPQMHQGHPGQHTPPSQNPNS
QSSGMPSPLYPWMRSQFGKCQGK*

Amino acids are the building blocks of proteins. Put very simplistically, our genes tell our bodies which amino acids to put into the proteins that we make, and it is the proteins that make up the significant constituents of our bodies. Myelin Basic Protein (MBP) is an example of one such protein. In order to understand how amino acids are glued together to make proteins, we must look at the DNA (deoxyribonucleic acid) that is present in almost all the cells in our bodies. DNA is built up of very many sub-units called neucleotides, each of which contains a chemical "base". There are only four different bases and thus only four different nucleotides. The four bases are adenine (A), thymine (T), cytosine (C) and guanine (G). Genes are sections of DNA, in which the neucleotides are viewed in groups of three called "triplets" or "codons". Each codon "codes" for a particular amino acid. A gene is terminated by a stop code or terminator which is represented by one of three codons that do not code for amino acids. There are 20 different amino acids that are used in animals (there are others that are used in plants). There are 64 different codons and most of the 20 amino acids are coded for by more than one triplet (see table below). The process of synthesing amino acids from genes is known as transcription. During transcription, a gene is echoed from the DNA into a complementary form called ribonucleic acid (RNA). From the RNA, amino acids are produced and are joined with one another with a peptide bond. The resulting sequence of amino acids is known as peptide string or polypeptide. Proteins are derived from these polypeptides.This table shows amino acid names, three- and one-letter standard abbreviations, and linear structures.

NameAbbreviation Linear Structure
Alanineala A CH3-CH(NH2)-COOH
Argininearg R HN=C(NH2)-NH-(CH2)3-CH(NH2)-COOH
Asparagineasn N H2N-CO-CH2-CH(NH2)-COOH
Aspartic Acidasp D HOOC-CH2-CH(NH2)-COOH
Cysteinecys C HS-CH2-CH(NH2)-COOH
Glutamic Acidglu E HOOC-(CH2)2-CH(NH2)-COOH
Glutaminegln Q H2N-CO-(CH2)2-CH(NH2)-COOH
Glycinegly G NH2-CH2-COOH
Histidinehis H NH-CH=N-CH=C-CH2-CH(NH2)-COOH
Isoleucineile I CH3-CH2-CH(CH3)-CH(NH2)-COOH
Leucineleu L (CH3)2-CH-CH2-CH(NH2)-COOH
Lysinelys K H2N-(CH2)4-CH(NH2)-COOH
Methioninemet M CH3-S-(CH2)2-CH(NH2)-COOH
Phenylalaninephe F Ph-CH2-CH(NH2)-COOH
Prolinepro P NH-(CH2)3-CH-COOH
Serineser S HO-CH2-CH(NH2)-COOH
Threoninethr T CH3-CH(OH)-CH(NH2)-COOH
Tryptophantrp W Ph-NH-CH=C-CH2-CH(NH2)-COOH
Tyrosinetyr Y HO-Ph-CH2-CH(NH2)-COOH
Valineval V (CH3)2-CH-CH(NH2)-COOH

The 20 Amino Acids and the stop code (Terminator)
AbbreviationAmino acid name Neucleotide sequences (codons)
AlaAlanine GCT, GCC, GCA, GCG
ArgArginine CGT, CGC, CGA, CGG, AGA, AGG
AsnAsparagine AAT, AAC
AspAspartic Acid GAT, GAC
CysCysteine TGT, TGC
GlnGlutamine CAA, CAG
GluGlutamic Acid GAA, GAG
GlyGlycine GGT, GGC, GGA, GGG
HisHistidine CAT, CAC
IleIsoleucine ATT, ATC, ATA
LeuLeucine TTG, TTA, CTT, CTC, CTA, CTG
LysLysine AAA, AAG
MetMethionine ATG
PhePhenylalanine TTT, TTC
ProProline CCT, CCC, CCA, CCG
SerSerine TCT, TCC, TCA, TCG, AGT, AGC
ThrThreonine ACT, ACC, ACA, ACG
TrpTryptophan TGG
TyrTyrosine TAT, TAC
ValValine GTT, GTC, GTA, GTG
EndTerminator TAA, TAG, TGA

other abbreviations:
Asx Aspartic Acid or Asparagine GAT,GAC,AAT,AAC

Glx Glutamic Acid or Glutamine GAA,GAG,CAA,CAG

Xxx or Xaa Unknown

where the derivation is uncertain or unknown

Musical expression of gene: Soundtrack: Musica Mundana Drosophila

 

Writing musically a fly

The attribute that the amino-acids of gene chain have, to be expressed with more from one ways, constitutes already, musically, a material of 'variants without subject'. The process of musical transcription that takes place in three stages (1. music of fly 2. hearing mutation 3. reintroduction fly of music) is not based on some system of musical notes, as usually in such cases, but in a line by territorial codes that are answered in the sound (acoustic phenomena decoded by the perception as information relative with the space that us surround as resonance, diffraction, aid/ absorption of concrete regions of spectrum, inversion of phase). In the first phase the gene of fly is persualed /readen musically. The second phase, via complex hearing and treatment, leads finally to the musical mutation of neutral ways of description of amino-acids of genetic chain. In the third phase the mutant genetic chain is musically implanted in the gene the new, musically written fly. H return of music in the fly leaves himself the fly inalterable, although genetically modified. The musical flies, though will fly with musical intervention in their gene, perhaps have rather involved , despite suffer change. (text by Vassilis Kokkas)

 

how music is derived from the thermal scanning of the performance space:

real time music transcription through MAX_MSP

_the music of the thyrsus is based on the song of the bird Blue Jay

_the sound wave diagram of the Blue Jay is also triangle shaped

sound sample of Blue Jay

Symbols molecular weights
A 89.09
R 174.20
N 132.12
D 133.10
C 121.15
E 146.15
Q 147.13
G 75.07
H 155.16
I 131.17
L 131.17
K 146.19
M 149.21
F 165.19
P 115.13
S 105.09
T 119.12
W 204.23
Y 181.19
V 117.15

 

 
AlaAlanine

L-Alanine is a neutral, genetically coded amino acid.

Symbol
ala a
Molecular formula
C3H7NO2
Molecular weight
89.09
Isoelectric point (pH)
6.00
pKa values
2.35, 9.87
CAS Registry Number
56-41-7

ArgArginine

Arginine
L-Arginine is a basic, genetically coded amino acid. It is essential for human development ("semi-essential").Symbol
arg r
Molecular formula
C6H14N4O2
Molecular weight
174.20
Isoelectric point (pH)
11.15
pKa values
2.18, 9.09, 13.2 (guanidine)
CAS Registry Number
74-79-3

AsnAsparagine Asparagine
L-Asparagine is a non-essential, neutral, genetically coded amino acid.Symbol
asn n
Molecular formula
C4H8N2O3
Molecular weight
132.12
Isoelectric point (pH)
5.41
pKa values
2.02, 8.80
CAS Registry Number
70-47-3
AspAspartic Acid

Aspartic Acid
L-Aspartic acid is a non-essential, acidic, genetically coded amino acid.Symbol
asp d
Molecular formula
C4H7NO4
Molecular weight
133.10
Isoelectric point (pH)
2.77
pKa values
1.88, 3.65, 9.60
CAS Registry Number
56-84-8

CysCysteine

Cysteine
L-Cysteine is a non-essential (or semi-essential), neutral, genetically coded amino acid.Symbol
cys c
Molecular formula
C3H7NO2S
Molecular weight
121.15
Isoelectric point (pH)
5.02
pKa values
1.71, 8.33 (thiol), 10.78
CAS Registry Number
52-90-4

GlnGlutamine

Glutamine
L-Glutamine is a non-essential, neutral, genetically coded amino acid.Symbol
gln q
Molecular formula
C5H10N2O3
Molecular weight
146.15
Isoelectric point (pH)
5.65
pKa values
2.17, 9.13
CAS Registry Number
56-85-9

GluGlutamic Acid

Glutamic Acid
L-Glutamic acid is a non-essential, acidic, genetically coded amino acid.Symbol
glu e
Molecular formula
C5H9NO4
Molecular weight
147.13
Isoelectric point (pH)
3.22
pKa values
2.19, 4.25, 9.67
CAS Registry Number
56-86-0

GlyGlycine

Glycine
Glycine is a non-essential, neutral, genetically coded amino acid. It is the only protein-forming amino acid without a center of chirality.Symbol
gly g
Molecular formula
C2H5NO2
Molecular weight
75.07
Isoelectric point (pH)
5.97
pKa values
2.21, 9.15
CAS Registry Number
56-40-6

HisHistidine

Histidine
L-Histidine is a basic, genetically coded amino acid. It is essential for human development ("semi-essential").Symbol
his h
Molecular formula
C6H9N3O2
Molecular weight
155.16
Isoelectric point (pH)
7.47
pKa values
1.78, 5.97 (imidazole), 8.97
CAS Registry Number
71-00-1

IleIsoleucine


Isoleucine
L-Isoleucine is a neutral, genetically coded amino acid. It is essential in human nutrition.Symbol
ile i
Molecular formula
C6H13NO2
Molecular weight
131.17
Isoelectric point (pH)
5.94
pKa values
2.32, 9.76
CAS Registry Number
73-32-5

LeuLeucine

Leucine
L-Leucine is a neutral, genetically coded amino acid. It is essential in human nutrition.Symbol
leu l
Molecular formula
C6H13NO2
Molecular weight
131.17
Isoelectric point (pH)
5.98
CAS Registry Number
61-90-5

LysLysine

Lysine
L-Lysine is a basic, genetically coded amino acid. It is essential in human nutrition (probably most limited in the food chain).Symbol
lys k
Molecular formula
C6H14N2O2
Molecular weight
146.19
Isoelectric point (pH)
9.59
pKa values
2.20, 8.90, 10.28
CAS Registry Number
56-87-1

MetMethionine

Methionine
L-Methionine is a neutral, genetically coded amino acid. It is essential in human nutrition.Symbol
met m
Molecular formula
C5H11NO2S
Molecular weight
149.21
Isoelectric point (pH)
5.74
pKa values
2.28, 9.21
CAS Registry Number
63-68-3

PhePhenylalanine

Phenylalanine
L-Phenylalanine is a neutral, genetically coded amino acid. It is essential in human nutrition.Symbol
phe f
Molecular formula
C9H11NO2
Molecular weight
165.19
Isoelectric point (pH)
5.48
pKa values
2.58, 9.24
CAS Registry

ProProline Proline
L-Proline is a non-essential, neutral, genetically coded amino acid. It is the only protein-forming amino acid with a secondary amino group.Symbol
pro p
Molecular formula
C5H9NO2
Molecular weight
115.13
Isoelectric point (pH)
6.30
pKa values
1.99, 10.60
CAS Registry
SerSerine Serine
L-Serine is a neutral, genetically coded amino acid.Symbol
ser s
Molecular formula
C3H7NO3
Molecular weight
105.09
Isoelectric point (pH)
5.68
pKa values
2.21, 9.15
CAS Registry Number
56-45-1
ThrThreonine

Threonine
L-Threonine is a neutral, genetically coded amino acid. It is essential in human nutrition.

Symbol
thr t
Molecular formula
C4H9NO3
Molecular weight
119.12
Isoelectric point (pH)
5.64
pKa values
2.15, 9.12
CAS Registry Number
72-19-5

TrpTryptophan Tryptophan
L-Tryptophan is a neutral, genetically coded amino acid. It is essential in human nutrition.

Symbol
trp w
Molecular formula
C11H12N2O2
Molecular weight
204.23
Isoelectric point (pH)
5.89
pKa-Werte
2.38, 9.39
CAS Registry Number
73-22-3

TyrTyrosine Tyrosine
L-Tyrosine is a non-essential (or semi-essential), neutral, genetically coded amino acid. It is very little soluble in water.

Symbol
tyr y
Molecular formula
C9H11NO3
Molecular weight
181.19
Isoelectric point (pH)
5.66
pKa values
2.20, 9.11, 10.07 (phenol)
CAS Registry Number
60-18-4

ValValine

Valine
L-Valine is a neutral, genetically coded amino acid. It is essential in human nutrition.

Symbol
val v
Molecular formula
C5H11NO2
Molecular weight
117.15
Isoelectric point (pH)
5.96
CAS Registry Number
72-18-4




William Blake

The Fly Little Fly,

Thy summer's play

My thoughtless hand Has brush'd away.

Am not I A fly like thee?

Or art not thou A man like me?

For I dance, And drink, and sing,

Till some blind hand Shall brush my wing.

If thought is life And strength and breath,

And the want Of thought is death;

Then am I A happy fly,

If I live Or if I die. _____________